![]() The central idea of this theory is that all physical reality, stretching from the so-called inanimate into the animate realm and from micro- to meso- to macrocosmic scales, can be interpreted and modeled as manifestations of a single geometric entity, the gyre. Because many elements of the gyre model ( gyromodel) are alien, I introduce neologisms and important terms in bold italics to identify them a theoretical lexicon is presented in Table 1. In the theory proposed herein, I use the heterodox yet simple gyre-a spiral, vortex, whorl, or similar circular pattern-as a core model for understanding life. The correct theory would be expected to not only explain how the living cell works now, but also to provide insight into the evolution of life on Earth. Several investigators have detailed what would be required of a unifying bioscientific theory. Insofar as the physical, chemical, and biological sciences are true, physical reality and life itself thus reflexively model such a scientific theory tautologically, the natural world subsumes said theory. ![]() The aim of a scientific theory is to construct a formal structure-in which the natural world is being modeled-to explain, predict, and control systems, events, and objects. Now, therefore, to know what life is and how life works, scientists need a scientifically accurate theory. In short, no consensus model for life has emerged. This hypothesis does not fit well with the central dogma and is unable to resolve precisely how the translation apparatus, genetic code, and biometabolic pathways evolved. Finally, the RNA (ribonucleic acid) world hypothesis posits that ribonucleotide-based genetic systems evolved prior to protein and deoxyribonucleic acid (DNA). However, this model does not explain the origin of genetic information, membrane systems, or the complexification or diversity of cellular structure. In the iron-sulfur world theory, primitive life is assumed to have started at deep-sea hydrothermal vents as a mineral base redox reactions provided the chemical energy to drive the emergence of cellular life. Though the soup model has matured in recent decades, it has difficulty explaining the exact conditions of the early Earth atmosphere and the manner and order of emergence of polymeric systems. The primordial soup hypothesis, also know as the Oparin-Haldane model, posits that during the early evolution of the Earth, a reducing atmosphere provided the correct environment for the formation of basic organic compounds. The problem with this group of models is that it does not, in an empirically complete and consistent manner, explain the molecular origin of the first cell and hence avoids the issue in need of solution. The panspermia hypothesis has many forms, some of which suggest that life started elsewhere in the universe and arrived on Earth by cometary, meteoric, or planetary delivery. Rather than give a comprehensive literature review, I introduce a handful of these ideas and point out their limitations. ![]() Solving this problem requires an interdisciplinary knowledge and an awareness of conventional theories, especially those related to the origin and evolution of life. How life abides by the second law of thermodynamics yet evolutionarily complexifies and maintains its intrinsic order is a fundamental mystery in physics, chemistry, and biology. ![]() The theoretical framework unifies the macrocosmic and microcosmic realms, validates predicted laws of nature, and solves the puzzle of the origin and evolution of cellular life in the universe. This theory is based upon a straightforward and non-mathematical core model and proposes unique yet empirically consistent explanations for major phenomena including, but not limited to, quantum gravity, phase transitions of water, why living systems are predominantly CHNOPS (carbon, hydrogen, nitrogen, oxygen, phosphorus, and sulfur), homochirality of sugars and amino acids, homeoviscous adaptation, triplet code, and DNA mutations. ![]() Here, I present a theoretical framework that economically fits evidence accumulated from examinations of life. Thus, the advancement of scientific understanding requires new models that resolve fundamental problems. Despite significant theoretical progress, experimental anomalies, paradoxes, and enigmas have revealed paradigmatic limitations. Life is an inordinately complex unsolved puzzle. ![]()
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